Abstract

Tissue engineering aims at creating biological tissues to improve or restore the function of diseased or damaged tissues. To enhance the performance of engineered tissues, it is required to recapitulate in vitro not only the composition but also the structural organization of native tissues. To this end, tissue engineering techniques are beginning to focus on generating micron-sized tissue modules having specific microarchitectural features that can be used alone as living filler in the damaged areas or serve as building blocks to engineer large biological tissues by a bottom-up approach. This work discusses the shortcomings related to traditional “top-down” strategies and the promises of emerging “bottom-up” approaches in creating engineered biological tissues. We first present an overview of the current tissue-building techniques and their applications, with an analysis of the potentiality and shortcomings of different approaches. We then propose and discuss a novel method for the biofabrication of connective-like micro tissues and how this technique can be translated to cardiac muscle fabrication.

" /> Abstract

Tissue engineering aims at creating biological tissues to improve or restore the function of diseased or damaged tissues. To enhance the performance of engineered tissues, it is required to recapitulate in vitro not only the composition but also the structural organization of native tissues. To this end, tissue engineering techniques are beginning to focus on generating micron-sized tissue modules having specific microarchitectural features that can be used alone as living filler in the damaged areas or serve as building blocks to engineer large biological tissues by a bottom-up approach. This work discusses the shortcomings related to traditional “top-down” strategies and the promises of emerging “bottom-up” approaches in creating engineered biological tissues. We first present an overview of the current tissue-building techniques and their applications, with an analysis of the potentiality and shortcomings of different approaches. We then propose and discuss a novel method for the biofabrication of connective-like micro tissues and how this technique can be translated to cardiac muscle fabrication.

"> Author Profile – Methodist Journal
Methodist Journal

FEATURED GUEST EDITOR

ISSUE INTRO

The Burgeoning Field of Cardio-Oncology

See More
RECOGNITIONS

Barry H. Trachtenberg Leads Issue on Cardio-Oncology

See More

REVIEW ARTICLES See More

Heart Failure in Relation to Anthracyclines and Other Chemotherapies

Heart Failure in Relation to Tumor-Targeted Therapies and Immunotherapies

The Role of Cardiovascular Imaging and Serum Biomarkers in Identifying Cardiotoxicity Related to Cancer Therapeutics

Prevention and Treatment of Chemotherapy-Induced Cardiotoxicity

Cardiovascular Toxicities of Radiation Therapy

Electrophysiologic Complications in Cancer Patients

Vascular Toxicity in Patients with Cancer: Is There a Recipe to Clarify Treatment?

Future Directions in Cardio-Oncology

CASE REPORTS See More

A Rare Case of Pancreatitis-Induced Thrombosis of the Aorta and Superior Mesenteric Artery

Anomalous Origin of the Right Coronary Artery from the Left Main Coronary Artery in the Setting of Critical Bicuspid Aortic Valve Stenosis

Simultaneous Transfemoral Mitral and Tricuspid Valve in Ring Implantation: First Case Report with Edwards Sapien 3 Valve

Uneventful Follow-Up 2 Years after Endovascular Treatment of a High Flow Iatrogenic Aortocaval Fistula Causing Pulmonary Hypertension and Right Heart Failure

MUSEUM OF HMH MULTIMODALITY IMAGING CENTER See More

Do Not Pass Flow: Microvascular Obstruction on Cardiac Magnetic Resonance After Reinfarction Following Primary Percutaneous Coronary Intervention

CLINICAL PERSPECTIVES See More

EXCERPTA

Cardio-Oncology, Then and Now: An Interview with Barry Trachtenberg

POINTS TO REMEMBER

Onconephrology: An Evolving Field

POINTS TO REMEMBER

Herbal Nephropathy

EXCERPTA

Rolling the Dice on Red Yeast Rice

EDITORIALS

Letter to the Editor in Response to “Cardiac Autonomic Neuropathy in Diabetes Mellitus”