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Molecular Genetics of Hypertrophic Cardiomyopathy

Author:

A. J. Marian

From Methodist OeBakey Heart Center and Baylor College of Medicine, Houston, Texas, US
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Abstract

Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium characterized by unexplained cardiac hypertrophy, a small left ventricle and increased left ventricular ejection fraction. HCM is the most common cause of sudden cardiac death (SCD) and a major cause of morbidity in the elderly. The prevalence of HCM is approximately 1 :500 in the young, general population and likely higher in older individuals because of age-dependent penetrance.1 There have been remarkable advances in molecular genetic studies of HCM that have potential implications in understanding the pathogenesis, early diagnosis, risk stratifications and development of new therapies.
How to Cite: 1. Marian AJ. Molecular Genetics of Hypertrophic Cardiomyopathy. Methodist DeBakey Cardiovascular Journal. 2005;1(2):21-24. DOI: http://doi.org/10.14797/mdcvj.55
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Published on 01 Jan 2005.
Peer Reviewed

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