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Biology of Aortic Aneurysms and Dissections

Authors:

Joseph S. Fernandez-Moure ,

Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, Texas, US
About Joseph S.
M.D.
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Daynene Vykoukal,

Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, Texas, US
About Daynene
Ph.D.
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Mark G. Davies

Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, Texas, US
About Mark G.
M.D., Ph.D., M.B.A.
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Abstract

The biology of aortic aneurysm and dissection has evolved to where we now understand the genetic implications of changes in extracellular matrix proteins, smooth muscle cells, and growth factors and how they affect aortic wall homeostasis. These predeterminants are influenced by smoking, hypertension, and atherosclerosis, and the result is an inflammatory response coupled to an accelerated proteolytic cascade that disrupts both elastin and collagen in the aortic wall.

How to Cite: 1. Fernandez-Moure JS, Vykoukal D, Davies MG. Biology of Aortic Aneurysms and Dissections. Methodist DeBakey Cardiovascular Journal. 2011;7(3):2-7. DOI: http://doi.org/10.14797/mdcvj.277
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Published on 01 Jul 2011.
Peer Reviewed

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