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Therapeutic Transdifferentiation: Can we Generate Cardiac Tissue Rather Than Scar after Myocardial Injury?

Authors:

Nazish Sayed ,

Houston Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, Texas, US
About Nazish
M.D., Ph.D.
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Wing Tak Wong,

Houston Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, Texas, US
About Wing Tak
Ph.D.
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John P. Cooke

Houston Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, Texas, US
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M.D., Ph.D.
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Abstract

After myocardial injury, the cardiac muscle does not regenerate and heals by forming a scar. This process results in loss of heart function and ultimately heart failure. Recent application of reprogramming technology, where forced expression of master regulators convert scar-forming cells to become cardiovascular cells in vivo, has fueled new hope for the development of therapies targeting heart disease.

How to Cite: 1. Sayed N, Wong WT, Cooke JP. Therapeutic Transdifferentiation: Can we Generate Cardiac Tissue Rather Than Scar after Myocardial Injury?. Methodist DeBakey Cardiovascular Journal. 2013;9(4):210-212. DOI: http://doi.org/10.14797/mdcj-9-4-210
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Published on 01 Oct 2013.
Peer Reviewed

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