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Mechanisms of Disease: Is Mitochondrial Function Altered in Heart Failure?

Author:

Dale J. Hamilton

Weill Cornell Medical College, New York, New York; Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, Texas, US
About Dale J.
M.D.
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Abstract

The human heart sustains an exceptional energy transfer rate, consuming more energy per gram weight than any other organ system. The healthy heart can rapidly adapt to changes in demand, while the failing heart cannot. Cardiac energy flux systems falter in the failing heart. The purpose of this review is to characterize the fundamental role of mitochondria in this energy transfer system and describe our local research on mitochondrial respiratory capacity in failing human hearts.

How to Cite: 1. Hamilton DJ. Mechanisms of Disease: Is Mitochondrial Function Altered in Heart Failure?. Methodist DeBakey Cardiovascular Journal. 2013;9(1):44-48. DOI: http://doi.org/10.14797/mdcj-9-1-44
Published on 01 Jan 2013.
Peer Reviewed

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