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The Role of B-Cells in Heart Failure

Authors:

Andrea M. Cordero-Reyes ,

Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, Texas, US
About Andrea M.
M.D.
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Keith A. Youker,

Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, Texas, US
About Keith A.
Ph.D.
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Guillermo Torre-Amione

Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, Texas, US; Catedra de Cardiologia y Medicina Vascular, Escuela de Medicina, Tecnológico De Monterrey, Monterrey, MX
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M.D., Ph.D.
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Abstract

Heart failure is a complex disease that has great impact on morbidity and mortality in the general population. No recent therapies have proven to be effective; however, the discovery of new potential pathophysiological mechanisms involved in heart failure expression and progression could offer novel therapeutic strategies. A number of studies have shown that the immune system may be a central mediator in the development and progression of heart failure, and here we describe how the B-cell and B-cellmediated pathways play specific roles in the heart failure state. Therapies aimed at B-cells, either blocking antibody productionor inactivating B-cell function, may suggest potential new treatment strategies.

How to Cite: 1. Cordero-Reyes AM, Youker KA, Torre-Amione G. The Role of B-Cells in Heart Failure. Methodist DeBakey Cardiovascular Journal. 2013;9(1):15-19. DOI: http://doi.org/10.14797/mdcj-9-1-15
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Published on 01 Jan 2013.
Peer Reviewed

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