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Critical Limb Ischemia: Epidemiology


Mark G. Davies

Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, Texas, US
About Mark G.
M.D., Ph.D., M.B.A.
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Critical limb ischemia is found in 12% of the U.S. adult population. Its clinical presentation varies from no symptoms to intermittent claudication, atypical leg pain, rest pain, ischemic ulcers, or gangrene. Those with critical limb ischemia have a high incidence of cardiovascular comorbidities that reflect a significant systemic atherosclerotic burden; they have increased functional impairment and increased rates of functional decline compared with persons without critical limb ischemia. Interventions for critical limb ischemia and the impact of major amputation have a significant social and economic impact. At 1 year, 25% of patients will be dead, 30% will have undergone amputation, and only 45% will remain alive with both limbs. At 5 years, more than 60% of patients with critical limb ischemia will be dead.

How to Cite: 1. Davies MG. Critical Limb Ischemia: Epidemiology. Methodist DeBakey Cardiovascular Journal. 2012;8(4):10-14. DOI:
Published on 01 Oct 2012.
Peer Reviewed


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