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Cytomegalovirus Localization in Atherosclerotic Plaques is Associated with Acute Coronary Syndromes: Report of 105 Patients

Authors:

Morteza Izadi ,

Health Research Center, Department of Infectious Diseases, Baqiyatallah University of Medical Sciences, Tehran, IR
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M.D.
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Mozhgan Fazel,

International Travel Medicine Center of Iran, Baqiyatallah University of Medical Sciences, Tehran, IR
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M.D.
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Seyed Hassan Saadat,

Behavioral Sciences Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR
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M.D.
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Mohammad Hassan Nasseri,

Health Research Center, Department of Infectious Diseases, Baqiyatallah University of Medical Sciences, Tehran; Department of Surgery, Baqiyatallah University of Medical Sciences, Tehran, IR
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M.D.
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Mojtaba Ghasemi,

Health Research Center, Department of Infectious Diseases, Baqiyatallah University of Medical Sciences, Tehran; Department of Cardiology, Baqiyatallah University of Medical Sciences, Tehran, IR
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M.D.
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Hossein Dabiri,

Department of Microbiology, Shahid Beheshti University of Medical Science, Tehran, IR
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Reza Safi Aryan,

Health Research Center, Department of Infectious Diseases, Baqiyatallah University of Medical Sciences, Tehran; Department of Surgery, Baqiyatallah University of Medical Sciences, Tehran, IR
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M.D.
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Ali Akbar Esfahani,

Health Research Center, Department of Infectious Diseases, Baqiyatallah University of Medical Sciences, Tehran, IR
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M.D.
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Ali Ahmadi,

Health Research Center, Department of Infectious Diseases, Baqiyatallah University of Medical Sciences, Tehran; Department of Laboratory Medicine, Shahid Beheshti University of Medical Science, Tehran, IR
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Davood Kazemi-Saleh,

Health Research Center, Department of Infectious Diseases, Baqiyatallah University of Medical Sciences, Tehran; Department of Cardiology, Baqiyatallah University of Medical Sciences, Tehran, IR
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Mohammad Hassan Kalantar-Motamed,

Health Research Center, Department of Infectious Diseases, Baqiyatallah University of Medical Sciences, Tehran; Department of Surgery, Baqiyatallah University of Medical Sciences, Tehran, IR
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M.D.
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Saeed Taheri

Dr. Taheri Medical Research Group, Tehran, IR
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Abstract

It has been shown that cytomegalovirus (CMV) is present in coronary atherosclerotic plaques, but the clinical relevance of this presence remains to be elucidated. In this study we sought to examine CMV infection in atherosclerosis patients defined by different methods and to identify the clinical significance of CMV replication in the atherosclerotic plaques. The study included 105 consecutive patients who were admitted to our department and underwent coronary artery bypass grafting (CABG) surgical interventions. Coronary atherosclerotic specimens as well as 53 specimens from the mamillary artery of these same patients were analyzed. Enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR) methods were used for evaluations. The CMV PCR test result was positive for 28 (26.7%) of patients with coronary artery atherosclerosis. After adjusting for other risk factors, coronary artery disease patients with a history of acute coronary syndrome were more likely to be positive for CMV PCR test (P = 0.027; odds ratio: 4.2; 95% CI: 1.18-15.0). They were also more likely to have a positive family history for cardiovascular diseases (CVD). This study confirms previous evidence about the replication of CMV virus in the atherosclerotic plaques of coronary arteries and brings clinical significance to this observation by showing a higher prevalence of acute coronary syndromes in those patients with CMV-infected plaques. Our study also suggests a familial vulnerability to CMV replication in the coronary artery walls.

How to Cite: 1. Izadi M, Fazel M, Saadat SH, et al.. Cytomegalovirus Localization in Atherosclerotic Plaques is Associated with Acute Coronary Syndromes: Report of 105 Patients. Methodist DeBakey Cardiovascular Journal. 2012;8(2):42-46. DOI: http://doi.org/10.14797/mdcj-8-2-42
Published on 01 Apr 2012.
Peer Reviewed

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