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Programmable Bio-NanoChip Technology for the Diagnosis of Cardiovascular Disease at the Point of Care

Authors:

Nicolaos Christodoulides ,

Rice University, Houston, Texas, US
About Nicolaos
Ph.D.
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Pierre N. Floriano,

Rice University, Houston, Texas, US
About Pierre N.
Ph.D.
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Ximena Sanchez,

Rice University, Houston, Texas, US
About Ximena
Ph.D.
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Luanyi Li,

Rice University, Houston, Texas, US
About Luanyi
B.Sc.
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Kyle Hocquard,

Rice University, Houston, Texas, US
About Kyle
B.A.
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Aaron Patton,

Rice University, Houston, Texas, US
About Aaron
B.A.
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Rachna Muldoon,

Rice University, Houston, Texas, US
About Rachna
B.A.
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Craig S. Miller,

University of Kentucky, Lexington, Kentucky, US
About Craig S.
D.M.D., M.S.
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Jeffrey L. Ebersole,

University of Kentucky, Lexington, Kentucky, US
About Jeffrey L.
Ph.D.
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Spencer Redding,

University of Texas Health Science Center in San Antonio, San Antonio, Texas, US
About Spencer

D.D.S., M.Ed.

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Chih-Ko Yeh,

University of Texas Health Science Center in San Antonio, San Antonio, Texas, US
About Chih-Ko
B.D.S., Ph.D.
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Wieslaw B. Furmaga,

University of Texas Health Science Center in San Antonio, San Antonio, Texas, US
About Wieslaw B.
M.D.
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David A. Wampler,

University of Texas Health Science Center in San Antonio, San Antonio, Texas, US
About David A.
Ph.D.
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Biykem Bozkurt,

Baylor College of Medicine, Houston, Texas, Michael E. DeBakey VA Medical Center, Houston, Texas, US
About Biykem
M.D., Ph.D.
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Christie M. Ballantyne,

Baylor College of Medicine, Houston, Texas; Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, Texas, US
About Christie M.
M.D.
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John T. McDevitt

Rice University, Houston, Texas, US
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Ph.D.
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Abstract

Cardiovascular disease remains the leading cause of death in the world and continues to serve as the major contributor to healthcare costs. Likewise, there is an ever-increasing need and demand for novel and more efficient diagnostic tools for the early detection of cardiovascular disease, especially at the point-of-care (POC). This article reviews the programmable bio-nanochip (P-BNC) system, a new medical microdevice approach with the capacity to deliver both high performance and reduced cost. This fully integrated, total analysis system leverages microelectronic components, microfabrication techniques, and nanotechnology to noninvasively measure multiple cardiac biomarkers in complex fluids, such as saliva, while offering diagnostic accuracy equal to laboratory-confined reference methods. This article profiles the P-BNC approach, describes its performance in real-world testing of clinical samples, and summarizes new opportunities for medical microdevices in the field of cardiac diagnostics.

How to Cite: 1. Christodoulides N, Floriano PN, Sanchez X, et al.. Programmable Bio-NanoChip Technology for the Diagnosis of Cardiovascular Disease at the Point of Care. Methodist DeBakey Cardiovascular Journal. 2012;8(1):6-12. DOI: http://doi.org/10.14797/mdcj-8-1-6
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Published on 01 Jan 2012.
Peer Reviewed

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