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Atrial Fibrillation and Hypertension: Mechanistic, Epidemiologic, and Treatment Parallels

Authors:

Adedotun A. Ogunsua ,

University of Massachusetts Medical School, Worcester, Massachusetts, US
About Adedotun A.
M.D., M.P.H.
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Amir Y. Shaikh,

University of Massachusetts Medical School, Worcester, Massachusetts, US
About Amir Y.
M.D.
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Mohamed Ahmed,

University of Massachusetts Medical School, Worcester, Massachusetts, US
About Mohamed
M.D.
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David D. McManus

University of Massachusetts Medical School, Worcester, Massachusetts, US
About David D.
M.D., Sc.M
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Abstract

Atrial fibrillation (AF) is an increasingly prevalent condition and the most common sustained arrhythmia encountered in ambulatory and hospital practice. Several clinical risk factors for AF include age, sex, valvular heart disease, obesity, sleep apnea, heart failure, and hypertension (HTN). Of all the risk factors, HTN is the most commonly encountered condition in patients with incident AF. Hypertension is associated with a 1.8-fold increase in the risk of developing new-onset AF and a 1.5-fold increase in the risk of progression to permanent AF. Hypertension predisposes to cardiac structural changes that influence the development of AF such as atrial remodeling. The renin angiotensin aldosterone system has been demonstrated to be a common mechanistic link in the pathogenesis of HTN and AF. Importantly, HTN is one of the few modifiable AF risk factors, and guideline-directed management of HTN may reduce the incidence of AF.

How to Cite: 1. Ogunsua AA, Shaikh AY, Ahmed M, McManus DD. Atrial Fibrillation and Hypertension: Mechanistic, Epidemiologic, and Treatment Parallels. Methodist DeBakey Cardiovascular Journal. 2015;11(4):228-234. DOI: http://doi.org/10.14797/mdcj-11-4-228
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Published on 01 Oct 2015.
Peer Reviewed

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