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ANA-Negative Lupus Presenting with Heart Failure and Severe Valvular Dysfunction: Case Report and Review of the Literature

Authors:

Vu Hoang ,

Baylor College of Medicine, Houston, Texas, US
About Vu
M.D.
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Daniel Addison,

Baylor College of Medicine, Houston, Texas, US
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M.D.
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Nasser Lakkis,

Baylor College of Medicine, Houston, Texas, US
About Nasser
M.D.
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Rashed Tabbaa

Baylor College of Medicine, Houston, Texas, US
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M.D.
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Abstract

Antinuclear antibody (ANA) negative lupus is an important subset of the systemic lupus erythematosus (SLE) disease spectrum. Since the introduction of human cell line for ANA assay, the occurrence of true ANA-negative SLE has been a rare clinical phenomenon. The nature of cardiac involvement in ANA-negative SLE is not well understood, although any cardiac involvement, including valvular dysfunction, should be considered as a presenting manifestation of SLE irrespective of serology status. Early recognition and intervention appears to be associated with decreased morbidity.

The following report describes our first case of ANA-negative SLE with an initial presentation of severe cardiac valvular dysfunction and heart failure. It also characterizes the spectrum of disease severity in ANA-negative SLE and demonstrates how aggressive SLE therapy can improve cardiac disease.

How to Cite: 1. Hoang V, Addison D, Lakkis N, Tabbaa R. ANA-Negative Lupus Presenting with Heart Failure and Severe Valvular Dysfunction: Case Report and Review of the Literature. Methodist DeBakey Cardiovascular Journal. 2015;11(3):186-188. DOI: http://doi.org/10.14797/mdcj-11-3-186
Published on 01 Jul 2015.
Peer Reviewed

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