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Reading: Endothelium-Derived Nitric Oxide as an Antiatherogenic Mechanism: Implications for Therapy

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Endothelium-Derived Nitric Oxide as an Antiatherogenic Mechanism: Implications for Therapy

Authors:

Roman A. Sukhovershin ,

Houston Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, Texas, US
About Roman A.
M.D., Ph.D.
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Gautham Yepuri,

Houston Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, Texas, US
About Gautham
Ph.D.
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Yohannes T. Ghebremariam

Houston Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, Texas, US
About Yohannes T.
Ph.D.
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Abstract

Endothelium-derived nitric oxide (eNO) is a multifunctional signaling molecule critically involved in the maintenance of metabolic and cardiovascular homeostasis. In addition to its role as a potent endogenous vasodilator, eNO suppresses key processes in vascular lesion formation and opposes atherogenesis. This review discusses eNO as an antiatherogenic molecule and highlights factors that influence its bioavailability and therapeutic approaches to restore or enhance its levels.

How to Cite: 1. Sukhovershin RA, Yepuri G, Ghebremariam YT. Endothelium-Derived Nitric Oxide as an Antiatherogenic Mechanism: Implications for Therapy. Methodist DeBakey Cardiovascular Journal. 2015;11(3):166-171. DOI: http://doi.org/10.14797/mdcj-11-3-166
Published on 01 Jul 2015.
Peer Reviewed

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