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Stem Cell Therapies in Patients with Single Ventricle Physiology

Authors:

Suguru Tarui ,

Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, JP
About Suguru
M.D.
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Shunji Sano,

Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, JP
About Shunji
M.D., Ph.D.
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Hidemasa Oh

Okayama University Hospital, Okayama, JP
About Hidemasa
M.D., Ph.D.
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Abstract

Single ventricle physiology, especially hypoplastic left heart syndrome, is one of the most high-risk lesions in children with congenital heart disease, and the ensuing heart failure remains as a major problem related to adverse outcomes in these patients. The field of stem cell therapy for heart failure has shown striking advances during the past 10 years, and many clinical trials using stem cell technologies have been conducted in adults, which suggest that stem cell therapy is associated with longterm improvement in cardiac function. Cardiac progenitor cells have recently been discovered, and their strong regenerative ability has been demonstrated in several studies. Although no large clinical trials have been performed in the field of congenital heart disease, recent investigations indicate that stem cell therapy may hold great potential to treat children with cardiac defects.

How to Cite: 1. Tarui S, Sano S, Oh H. Stem Cell Therapies in Patients with Single Ventricle Physiology. Methodist DeBakey Cardiovascular Journal. 2014;10(2):77-81. DOI: http://doi.org/10.14797/mdcj-10-2-77
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Published on 01 Apr 2014.
Peer Reviewed

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