Review Articles

Combined Heart-Kidney Transplantation: Indications, Outcomes, and Controversies



Renal dysfunction, a prevalent comorbidity in advanced heart failure, is associated with significant morbidity and mortality after heart transplantation. In the recent era, the field of combined heart-kidney transplantation has experienced great success in the treatment of both renal and cardiac dysfunction in end-stage disease states, and the number of transplants has increased dramatically. In this review, we discuss appropriate indications and selection criteria, overall and organ-specific outcomes, and future perspectives in the field of combined heart-kidney transplantation.


orthotopic heart transplantationdeceased donor kidney transplantationchronic kidney diseaseheart-kidney transplantationtransplant
  • Year: 2022
  • Volume: 18 Issue: 4
  • Page/Article: 11-18
  • DOI: 10.14797/mdcvj.1139
  • Submitted on 21 May 2022
  • Accepted on 8 Jul 2022
  • Published on 6 Sep 2022
  • Peer Reviewed