Review Articles

Critical Limb Ischemia: Epidemiology



Critical limb ischemia is found in 12% of the U.S. adult population. Its clinical presentation varies from no symptoms to intermittent claudication, atypical leg pain, rest pain, ischemic ulcers, or gangrene. Those with critical limb ischemia have a high incidence of cardiovascular comorbidities that reflect a significant systemic atherosclerotic burden; they have increased functional impairment and increased rates of functional decline compared with persons without critical limb ischemia. Interventions for critical limb ischemia and the impact of major amputation have a significant social and economic impact. At 1 year, 25% of patients will be dead, 30% will have undergone amputation, and only 45% will remain alive with both limbs. At 5 years, more than 60% of patients with critical limb ischemia will be dead.


critical limb ischemiacardiovascular diseasecardiovascular risk factorsclaudicationperipheral arterial diseaseamputation
  • Year: 2012
  • Volume: 8 Issue: 4
  • Page/Article: 10-14
  • DOI: 10.14797/mdcj-8-4-10
  • Published on 1 Oct 2012
  • Peer Reviewed