Sinus of Valsalva aneurysm (SOVA) is a rare condition that is often asymptomatic but has various presentations, including rupture that could be fatal.1,2 We hereby present a case of a large unruptured SOVA complicated by thrombus formation and compression of the left atrium and left ventricular outflow tract, highlighting the importance of prompt diagnosis and the condition's associated diagnostic challenges.


A 67-year-old man with a history of hypertension but no history of cigarette smoking, connective tissue disease, or chest trauma presented after a single episode of chest pain. Ten years prior to presentation, he had a diagnostic coronary angiogram that showed nonobstructive coronary artery disease. On presentation, he denied dyspnea, orthopnea, palpitations, syncope, or lower extremity edema. A basic laboratory work-up and cardiopulmonary examination were both unremarkable, and a 12-lead electrocardiogram (ECG) did not show any notable changes. Transthoracic echocardiogram (TTE) showed normal left ventricular function with no regional wall motion abnormalities. However, the aortic root was significantly enlarged at the sinus of Valsalva, measuring 5.3 cm. On close examination, the noncoronary cusp of the aortic valve appeared aneurysmal, representing a SOVA (Figure 1 A). Computer tomography (CT) of the thorax with ECG gating was obtained for further evaluation, and the sinus of Valsalva measured 5.6 cm on the coronal plane on CT. A circumferential area of low density was also visualized around the noncoronary cusp, suggestive of a thrombus or a previous thrombosed dissection (Figure 1 B). Cardiothoracic surgery was consulted to evaluate for surgical management. As part of the preoperative evaluation, coronary angiogram was deferred given the high risk of thrombus embolization; however, a coronary CT angiogram was performed and showed 50 to 60 focal stenosis of the left anterior descending artery (LAD) mid segment. The noncoronary sinus aneurysm of the aortic valve with a large thrombus was seen again. The aneurysm exerted mass effect on the anterior wall of the left atrium and led to narrowing of the left ventricular outflow tract; however, this was not apparent on the transthoracic or transesophageal echocardiograms on 2-dimensional images, and there were no hemodynamically significant Doppler effects.

Figure 1. 

(A) Transthoracic echocardiogram shows a filling defect within the noncoronary cusp after administration of ultrasound contrast, suggestive of a thrombus. (B) Computed tomography coronary angiogram shows aneurysmal noncoronary sinus (indicates dilated noncoronary cusp aneurysm, arrow indicates thrombus). (C) Intraoperative image shows aortic root at the level of sinus of Valsalva and the noncoronary cusp aneurysm (arrow).

Since the thrombus was likely chronic in nature and there was concern for a paradoxical increase in thromboembolism risk, anticoagulation was not started. The patient eventually underwent surgical aortic aneurysm repair with a single left internal mammary artery-LAD bypass and mechanical aortic valve conduit. Intraoperatively, a tear was seen posteriorly through the intervalvular fibrosa onto the roof of the left atrium, suggesting prior dissection. The patient tolerated surgery without complications and was discharged on warfarin. He was doing well on follow-up and had no chest pain. It was difficult to conclude whether or not his prior chest pain on initial presentation was related to the SOVA, but we could not find any other clear explanation. Nevertheless, it did ultimately expose the SOVA and was no longer present after the surgery.


Aneurysm of the sinus of Valsalva is so rare that a review of 8,138 autopsies found it in only 0.09 of participants.1 SOVA can be congenital or acquired, and etiologies for the latter include infections such as bacterial endocarditis, syphilis, tuberculosis, trauma, connective tissue diseases, vasculitis, and chronic changes of atherosclerosis.1 Although our patient did not report a history of trauma, the finding of a separation between the left ventricle and the medial wall of the SOVA points to trauma as the potential etiology.

Unruptured SOVA is generally asymptomatic. Between 30 and 50 of patients present with progressive dyspnea secondary to aortic regurgitation. They may also present with arrhythmia since atrial fibrillation and complete heart block have been reported. A review of 177 patients with unruptured SOVA showed that 14 were asymptomatic, 56 had dyspnea, 46 had chest pain, 18 had palpitations, and 57 had murmur on exam.1 In this case, the SOVA was compressing the left atrium and left ventricular outflow tract, which possibly resulted in chest pain.

While invasive aortogram has historically been the gold standard for diagnosing SOVA, noninvasive imaging modalities are increasingly being used.1,3 In fact, compared to surgical findings, TTE was found to be 93.9 sensitive and 99.9 specific in diagnosing SOVA.4 Computed tomography adds additional value when evaluating patients with SOVA, particularly if aortocardiac shunts are present. In this case, cardiac CT allowed for evaluation of coronary anatomy as well. Cardiac magnetic resonance imaging has also been used to evaluate SOVA and surrounding anatomy in great detail. Of note, a particular diagnostic consideration in this case was the use of CT angiography rather than conventional angiography to evaluate coronary anatomy due to the high embolic risk with catheter manipulation. There have been reported cases of mural thrombi or calcifications causing blockage of the coronary artery ostium.2

Thrombus formation in the aorta is uncommon due to high blood flow velocity. A SOVA is a potential site of thrombus formation because it causes turbulent blood flow and stasis.5 Optimal treatment for sinus of Valsalva thrombus remains poorly defined since most guidance is via case reports with surgery as the main treatment.6, 8 However, there are reports of successful treatment with anticoagulation alone.9 For instance, in a case report of thrombus formation in a left coronary cusp SOVA, the patient was treated with 4 months of anticoagulation.8 In our case, the decision was made not to start the patient on anticoagulation because of the chronicity of the thrombus, potential risk of clot destabilization, and immediate plan for surgery within days.8

There is limited data on managing patients with SOVA. Surgical correction of unruptured SOVA has been used for definitive treatment with the goal of preventing rupture.8 In a review of 19 cases in which patients presented with chest pain attributed to unruptured SOVA that interfered with coronary flow, 9 were treated surgically. Among the 10 patients not treated surgically, 5 experienced fatal myocardial infarction. None of them had a thrombus in the SOVA.8 In one case of SOVA in the right coronary cusp complicated by atherothrombosis, surgical repair was performed with patch placement over an intimal tear to prevent rupture. A review of 15 cases of patients with ascending aorta thrombus found that 27 who were treated with anticoagulation alone suffered recurrent embolism.5 It was for that reason that surgical repair was considered the appropriate course of action for our patient. For ruptured SOVA, immediate surgery is the treatment of choice.10

Percutaneous closure of a ruptured SOVA with a patch has also been reported. In a review of SOVA cases in which 20 and 15 patients were treated surgically and percutaneously, respectively, there was no statistically significant difference in success rate, mortality, or New York Heart Association class on postoperative evaluation.10 Of note, none of the patients in those cases also had thrombus formation in the SOVA.


SOVA is a rare aortic abnormality that can potentially be acquired through inflammation, trauma, or connective tissue disease. TTE is the most common method for initial diagnosis. The aneurysm creates an environment of blood stasis and hence a nidus for thrombus formation. Coronary angiogram should be avoided in these patients given the risk of embolism with catheter manipulation. Surgical repair remains the standard of care for unruptured SOVA.