Spontaneous Closure of a Secundum Atrial Septal Defect
- Stephen Y. WangEmail Stephen Y. Wang
- Terrence D. Welch
- Aryé Elfenbein
- Aaron V. Kaplan
Spontaneous closure of an atrial septal defect (ASD) is well described in pediatric cardiology but may be less familiar to adult internists and cardiologists. We report a moderately sized 6-mm ASD that closed spontaneously without intervention. A literature review found that a smaller defect size and an early age of diagnosis are the most important predictors of closure. Possible mechanisms of a spontaneous ASD closure include adaptive endothelial migration, limited myocardial proliferation, and fibroblast migration with extracellular matrix deposition.
- Published on 1 Jan 2018
- Peer Reviewed