Case Reports

Spontaneous Closure of a Secundum Atrial Septal Defect



Spontaneous closure of an atrial septal defect (ASD) is well described in pediatric cardiology but may be less familiar to adult internists and cardiologists. We report a moderately sized 6-mm ASD that closed spontaneously without intervention. A literature review found that a smaller defect size and an early age of diagnosis are the most important predictors of closure. Possible mechanisms of a spontaneous ASD closure include adaptive endothelial migration, limited myocardial proliferation, and fibroblast migration with extracellular matrix deposition.


cardiologycongenital heart diseaseatrial septal defect
  • Year: 2018
  • Volume: 14 Issue: 1
  • Page/Article: 60-62
  • DOI: 10.14797/mdcj-14-1-60
  • Published on 1 Jan 2018
  • Peer Reviewed