Review Articles

Cardiovascular Disease in Acromegaly



In patients with acromegaly, chronic excess of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) leads to the development of acromegalic cardiomyopathy. Its main features are biventricular hypertrophy, diastolic dysfunction, and in later stages, systolic dysfunction and congestive heart failure. Surgical and/or pharmacological treatment of acromegaly and control of cardiovascular risk factors help reverse some of these pathophysiologic changes and decrease the high risk of cardiovascular complications.


acromegalyheart failurecardiomyopathyhypertensioncoronary artery diseasearrhythmiavalvular heart disease
  • Year: 2017
  • Volume: 13 Issue: 2
  • Page/Article: 64-67
  • DOI: 10.14797/mdcj-13-2-64
  • Published on 1 Apr 2017
  • Peer Reviewed