Review Articles

Cardiovascular Disease in Acromegaly

Authors:

Abstract

In patients with acromegaly, chronic excess of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) leads to the development of acromegalic cardiomyopathy. Its main features are biventricular hypertrophy, diastolic dysfunction, and in later stages, systolic dysfunction and congestive heart failure. Surgical and/or pharmacological treatment of acromegaly and control of cardiovascular risk factors help reverse some of these pathophysiologic changes and decrease the high risk of cardiovascular complications.

Keywords:

acromegalyheart failurecardiomyopathyhypertensioncoronary artery diseasearrhythmiavalvular heart disease
  • Year: 2017
  • Volume: 13 Issue: 2
  • Page/Article: 64-67
  • DOI: 10.14797/mdcj-13-2-64
  • Published on 1 Apr 2017
  • Peer Reviewed