Review Articles

Local Inhibition of Macrophage and Smooth Muscle Cell Proliferation to Suppress Plaque Progression



Atherosclerosis is a complex process responsible for a major burden of cardiovascular morbidity and mortality. Macrophages and smooth muscle cells (SMCs) are abundant within atherosclerotic plaques. This review discusses the role of macrophages and SMCs in plaque progression and provides an overview of nanoparticle-based approaches and other current methods for local targeting of atherosclerotic plaques.


atherosclerosisplaquemacrophagesmooth muscle cellnanoparticlenanotechnology
  • Year: 2016
  • Volume: 12 Issue: 3
  • Page/Article: 141-145
  • DOI: 10.14797/mdcj-12-3-141
  • Published on 1 Jul 2016
  • Peer Reviewed