Therapeutic Transdifferentiation: Can we Generate Cardiac Tissue Rather Than Scar after Myocardial Injury?
Nazish Sayed, Wing Tak Wong, and John P. Cooke. Therapeutic Transdifferentiation: Can we Generate Cardiac Tissue Rather Than Scar after Myocardial Injury?. Methodist DeBakey Cardiovascular Journal: October 2013, Vol. 9, No. 4, pp. 210-212.doi: https://doi.org/10.14797/mdcj-9-4-210
After myocardial injury, the cardiac muscle does not regenerate and heals by forming a scar. This process results in loss of heart function and ultimately heart failure. Recent application of reprogramming technology, where forced expression of master regulators convert scar-forming cells to become cardiovascular cells in vivo, has fueled new hope for the development of therapies targeting heart disease.Keywords
transdifferentiation , cardiomyocytes , cardiovascular diseases , transflammation , cardiovascular regeneration