Strategies to treat asymptomatic hyperuricemia should be considered in high-risk individuals to prevent progression of cardiovascular disease and chronic kidney disease.

" /> Strategies to treat asymptomatic hyperuricemia should be considered in high-risk individuals to prevent progression of cardiovascular disease and chronic kidney disease.

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IN THIS ISSUE

Adult Congenital Heart Update

Vol 15, Issue 2 (2019)


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ISSUE INTRO

The Growing Number of Adults Surviving with Congenital Heart Disease

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RECOGNITIONS

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Pulmonary Valve Replacement for Tetralogy of Fallot

Management of the Adult with Arterial Switch

Ebstein’s Anomaly

Heart Transplantation in Adults with Congenital Heart Disease

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Device-Related Thrombus: A Reason for Concern?

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POINTS TO REMEMBER

The Kidney in Congenital Cyanotic Heart Disease

EXCERPTA

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Lipids and Renal Disease

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Addressing the Feedback Loop Between Depression, Diabetes, and Cardiovascular Disease

EDITORIALS

Letter to the Editor in Response to “Cardiac Autonomic Neuropathy in Diabetes Mellitus”

Vol 4, Issue 1 (2008)

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Serum Uric Acid: An Independent Risk Factor For Vascular Injury

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Article Citation:

Juan Jorge Olivero and Juan Jose Olivero (2008) Serum Uric Acid: An Independent Risk Factor For Vascular Injury. Methodist DeBakey Cardiovascular Journal: January 2008, Vol. 4, No. 1, pp. 14-16.

doi: https://doi.org/10.14797/mdcj-4-1-14

Abstract

Hyperuricemia (serum uric acid levels >8mg/dL) has been associated with hypertension for a long time.1 At some point it was felt that elevated uric acid levels were the result of decreased kidney function, but recent clinical and experimental data have shown a direct correlation between high uric acid levels and progression of vascular injury, leading to increased cardiovascular morbidity and mortality, hypertension, and accelerated loss of kidney function.2 The mechanism of action appears to be mediated by the profound effects of uric acid in human vascular cells, which include endothelial dysfunction, vascular proliferation, and nitric oxide release from vascular cells.3–5 Moreover, as a consequence of afferent arteriolar injury by hyperuricemia, chronic tubulointerstitial changes leading to progressive loss of kidney function and worsening hypertension can occur.6

Strategies to treat asymptomatic hyperuricemia should be considered in high-risk individuals to prevent progression of cardiovascular disease and chronic kidney disease.

Keywords
hyperuricemia , serum uric acid , hypertension , chronic kidney disease , cardiovascular disease

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