Methodist Journal

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ISSUE INTRO

The Scourge of Cardiogenic Shock

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RECOGNITIONS

Arvind Bhimaraj, MD, MPH, Guides Issue on Cardiogenic Shock

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REVIEW ARTICLES See More

Cardiovascular Implications of COVID-19 Infections

Pathophysiology and Advanced Hemodynamic Assessment of Cardiogenic Shock

Cardiogenic Shock in the Setting of Acute Myocardial Infarction

Cardiogenic Shock in Patients with Advanced Chronic Heart Failure

Acute Mechanical Circulatory Support for Cardiogenic Shock

Management of Cardiogenic Shock in a Cardiac Intensive Care Unit

Physiological Concepts of Cardiogenic Shock Using Pressure-Volume Loop Simulations: A Case-Based Review

Systems of Care in Cardiogenic Shock

CASE REPORTS See More

COVID-19: A Potential Risk Factor for Acute Pulmonary Embolism

Repair of Extent III Thoracoabdominal Aneurysm in the Presence of Aortoiliac Occlusion

Williams-Beuren Syndrome: The Role of Cardiac CT in Diagnosis

A Rare Case of Pancreatitis-Induced Thrombosis of the Aorta and Superior Mesenteric Artery

MUSEUM OF HMH MULTIMODALITY IMAGING CENTER See More

A T2-Weighty Discovery: Aortitis on Cardiac MRI with Histopathologic Correlation

CLINICAL PERSPECTIVES See More

POINTS TO REMEMBER

Acute Kidney Injury in Cardiogenic Shock

EXCERPTA

Cardio-Oncology, Then and Now: An Interview with Barry Trachtenberg

POINTS TO REMEMBER

Onconephrology: An Evolving Field

POINTS TO REMEMBER

Herbal Nephropathy

EDITORIALS

Letter to the Editor in Response to “Cardiac Autonomic Neuropathy in Diabetes Mellitus”

Vol 16, Issue 1 (2020)

Article Full Text

CLINICAL PERSPECTIVES

Acute Kidney Injury in Cardiogenic Shock

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Article Citation:

Patel A, Nguyen P. Acute Kidney Injury in Cardiogenic Shock. Methodist DeBakey Cardiovasc J. 2020;16(1):68.



This column is supplied by Amol Patel, DO, and Peter Nguyen, MD. Dr. Patel is an internal medicine resident at Houston Methodist Hospital, where he is in his final year as chief resident. He received his bachelor’s degree in biomedical engineering at Texas A&M University and his medical degree at UNT Health Science center in Forth Worth, Texas. Dr. Nguyen is a nephrologist with Houston Kidney Consultants and practices at Houston Methodist Hospital, where he is currently the secretary of the medical staff. He obtained his medical degree from Texas Tech School of Medicine and completed his residency and nephrology fellowship at Baylor College of Medicine in Houston, Texas.

Cardiogenic shock (CS) can be a fatal complication of decompensated heart failure. This condition is associated with multiorgan failure, including acute kidney injury. The following are points to remember when diagnosing and treating acute kidney injury in patients with CS.

  • Acute kidney injury (AKI) is characterized by an abrupt decrease in glomerular filtration rate (GFR) and/or urine output. This is defined by a rise in serum creatinine ? 0.3 mg/dL from baseline or 5 to 1.9 times baseline, or a urine output ? 0.50 mL/kg/hr for at least 6 hours.1
  • AKI is associated with increased mortality in both inpatient and outpatient settings, with larger increases in serum creatinine predicting worse outcomes.In comparing the incidence of AKI and its relation to mortality among hospitalized patients, Wang et al. found that AKI with a 150% to 199% increase in baseline creatinine correlated with 6.3% mortality, while a 200% to 299% increase in creatine raised mortality to 16.5%, and > 300% raised mortality to 23.7%.2
  • In patients with CS, early AKI is a predictor of increased morbidity and mortality. Tarvasmäk et al. showed that 72% of their patients who developed AKI within the first 48 hours of CS detection ultimately required cardiac support with an intra-aortic balloon pump, whereas only 50% with CS alone needed the device. Twenty-eight percent of patients with early AKI ultimately underwent renal replacement therapy during their hospitalization, as opposed to only 8% in those who did not develop AKI in the first 48 hours. Patients with CS had a 70% 90-day mortality with early AKI but only 24% if renal function was preserved in the first 48 hours.3
  • As the stroke volume of the decompensated heart diminishes in CS, the overall cardiac output decreases. This leads to a decrease in overall effective arterial blood volume, resulting in end-organ damage and thus AKI. Treatment to augment cardiac output includes inotropic therapy and mechanical assist devices.
  • Poor cardiac output in CS leads to increased venous congestion. Renal vascular congestion results in lower arterial perfusion pressure and decreased GFR. Monitoring central venous pressure (CVP) is essential to determine whether diuretics are necessary. High CVP is thought to be a key physiologic factor causing AKI in CS.
  • Moreover, CVP is an independent predictor of AKI.Patients with CS and AKI have higher CVP and lower end-diastolic pressure and mean perfusion pressure, and they are treated with higher doses of inotropic therapy. They also have higher maximal ventilator pressures.4
  • Nonhemodynamic factors of acute heart failure and CS relate to activation of the renin-angiotensin-aldosterone cascade, which decreases GFR, causes hyporesponsivenessto natriuretic peptide, moderates sympathetic nervous system activation, and promotes renal fibrosis.5
  • AKI from CS often results in acute tubular necrosis and subsequent oliguria or anuria. In some cases, diuretic therapy is not effective, and patients need renal replacement therapy. If there is significant hemodynamic compromise, continuous renal replacement therapy may be preferred over intermittent hemodialysis.
References
  1. Khwaja A. KDIGO clinical practice guidelines for acute kidney injury. Nephron Clin Pract. 2012;120(4):c179–84.
  2. Wang HE, Muntner P, Chertow GM, Warnock DG. Acute kidney injury and mortality in hospitalized patients. Am J Nephrol. 2012;35(4):349-55.
  3. Tarvasmäki T, Haapio M, Mebazaa A, et al.; CardShock Study Investigators. Acute kidney injury in cardiogenic shock: definitions, incidence, haemodynamicalterations, and mortality. Eur J Heart Fail. 2018 Mar;20(3):572-581.
  4. Van den Akker JP, Bakker J, Groeneveld ABJ, den Uil CA. Risk indicators for acute kidney injury in cardiogenic shock. J Crit Care. 2019 Apr;50:11-16.
  5. Damman K, Testani JM. The kidney in heart failure: anEuro Heart J. 2015 Jun 14;36(23):1437-44.

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